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Article

Identification of Hedgehog pathway responsive glioblastomas by isocitrate dehydrogenase mutation.

Cancer letters - 28 Jan 2013

Gerardo Valadez J, Grover Vandana K, Carter Melissa D, Calcutt M Wade, Abiria Sunday A, Lundberg Christopher J, Williams Thomas V, Cooper Michael K

Abstract excerpt

The Hedgehog (Hh) pathway regulates the growth of a subset of adult gliomas and better definition of Hh-responsive subtypes could enhance the clinical utility of monitoring and targeting this pathway in patients. Somatic mutations of the isocitrate dehydrogenase (IDH) genes occur frequently in WH...

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Identifiers

PMID: 23063752
DOI: 10.1016/j.canlet.2012.10.002
PMCID: PMC4308293

Genes

PTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23063752-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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