Article
Different biological activities in conditioned media control the expression of a variety of neuropeptides in cultured sympathetic neurons.
Neuron - 1 Feb 1990
Nawa H, Sah D W
Abstract excerpt
An intriguing question regarding neuronal development is how neurons choose which neurotransmitter and/or peptide to express among over 40 candidates. We find that heart cell conditioned medium (CM) induces a number of neuropeptides and/or their precursor mRNAs, as well as acetylcholine, in cultured rat sympathetic neurons: substance P, somatostatin, vasoactive intestinal polypeptide, enkephalin derivatives, and...
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