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Article

Altered decidual DC-SIGN+ antigen-presenting cells and impaired regulatory T-cell induction in preeclampsia.

The American journal of pathology - 1 Dec 2012

Hsu Peter, Santner-Nanan Brigitte, Dahlstrom Jane E, Fadia Mitali, Chandra Arin, Peek Michael, Nanan Ralph

Abstract excerpt

Regulatory T (Treg) cell expansion is required for tolerance of the semi-allogeneic fetus in healthy pregnancy and impaired in preeclampsia in humans. However, the reasons remain unknown. Herein, we show that expansion of CD4(+)Helios(-)Foxp3(+) adaptive Treg (iTreg) cells, rather than CD4(+)Helios(+)Foxp3(+) natural Treg cells, accounts for this expansion in healthy pregnancy. This expansion is even more...

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Identifiers

PMID: 23063509
DOI: 10.1016/j.ajpath.2012.08.032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Altered decidual DC-SIGN+ antigen-presenting cells and impaired regulatory T-cell induction in preeclampsia.PMID 23063509Read ↗

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