Article
Maternal Foxp3 expressing CD4+ CD25+ and CD4+ CD25- regulatory T-cell populations are enriched in human early normal pregnancy decidua: a phenotypic study of paired decidual and peripheral blood samples.
American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Jul 2011
Dimova Tanya, Nagaeva Olga, Stenqvist Ann-Christin, Hedlund Malin, Kjellberg Lennart, Strand Magnus, Dehlin Eva, Mincheva-Nilsson Lucia
Abstract excerpt
PROBLEM: Regulatory T cells (Treg cells), a small subset of CD4(+) T cells maintaining tolerance by immunosuppression, are proposed contributors to the survival of the fetal semiallograft. We investigated Treg cells in paired decidual and peripheral blood (PB) samples from healthy women in early pregnancy and PB samples from non-pregnant women. METHOD OF STUDY: Distribution, location, cytokine mRNA, and phenotype...
Topics
- Antigens, CD
- CD4-Positive T-Lymphocytes
- Cytokines
- Decidua
- Female
- Forkhead Transcription Factors
- Humans
- Neuropilin-1
- OX40 Ligand
- Phenotype
- Pregnancy
- T-Lymphocytes, Regulatory