Article
Mash1 expression is induced in neuroendocrine prostate cancer upon the loss of Foxa2.
The Prostate - 1 May 2013
Gupta Aparna, Yu Xiuping, Case Tom, Paul Manik, Shen Michael M, Kaestner Klaus H, Matusik Robert J
Abstract excerpt
Neuroendocrine (NE) prostate tumors and neuroendocrine differentiation (NED) in prostatic adenocarcinomas have been associated with poor prognosis. In this study, we used the TRAMP mouse model that develops NE prostate tumors to identify key factors that can lead to NED. We have previously reported that NE tumors express the forkhead transcription factor, Foxa2, Mash1 (mouse achaete scute homolog-1), as well as...
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