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Article

Regulation of immediate-early gene transcription following activation of Gα(q)-coupled designer receptors.

Journal of cellular biochemistry - 1 Mar 2013

Kaufmann Anke, Keim Anja, Thiel Gerald

Abstract excerpt

G-protein coupled designer receptors that are specifically activated by designer drugs have been developed. Here, we have analyzed the regulation of gene transcription following activation of Gα(q)-coupled designer receptor (Rα(q)). Stimulation of human embryonic kidney (HEK) 293 cells expressing Rα(q) with clozapine-N-oxide (CNO), a pharmacologically inert compound, induced the expression of biologically active...

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Source

Identifiers

PMID: 23059951
DOI: 10.1002/jcb.24410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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