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Article

A high frequency of MSH6 G268A polymorphism and survival association in glioblastoma.

The International journal of neuroscience - 1 Feb 2013

Pei Chunying, Chen Hui, Jia Xiuzhi, Yan Lei, Zou Yan, Jiang Chuanlu, Jin Hua, Kang Chunsheng, Jiang Tao, Ren Huan

Abstract excerpt

MSH6 (mutS homolog 6), one of the five key mismatch repair (MMR) genes, was found to play an important role in conferring resistance to alkylating agents-temozolomide (TMZ) in malignant glioma. This study aims to investigate whether genetic variations in MSH6 gene are associated with the survival outcomes in patients with malignant glioma. Each exon of the MSH6 gene was sequenced, and single nucleotide...

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Source

Identifiers

PMID: 23057844
DOI: 10.3109/00207454.2012.738735

Genes

MSH6
MGMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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