Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08.

doi:10.1002/ana.23691

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Article

Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08.

Annals of neurology - 1 Dec 2012

Gregersen Peter K, Kosoy Roman, Lee Annette T, Lamb Janine, Sussman Jon, McKee David, Simpfendorfer Kim R, Pirskanen-Matell Ritva, Piehl Frederik, Pan-Hammarstrom Qiang, Verschuuren Jan J G M, Titulaer Maarten J, Niks Erik H, Marx Alexander, Ströbel Philipp, Tackenberg Björn, Pütz Michael, Maniaol Angelina, Elsais Ahmed, Tallaksen Chantal, Harbo Hanne F, Lie Benedicte A, Raychaudhuri Soumya, de Bakker Paul I W, Melms Arthur, Garchon Henri-Jean, Willcox Nicholas, Hammarstrom Lennart, Seldin Michael F

Abstract excerpt

OBJECTIVE: The objective of this study is to comprehensively define the genetic basis of early onset myasthenia gravis (EOMG). METHODS: We have carried out a 2-stage genome-wide association study on a total of 649 North European EOMG patients. Cases were matched 1:4 with controls of European ance...

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Identifiers

PMID: 23055271
DOI: 10.1002/ana.23691
PMCID: PMC3535539

Genes

TNIP1
PTPN22
TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23055271-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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