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Article

Approaches to informed consent for hypothesis-testing and hypothesis-generating clinical genomics research.

BMC medical genomics - 10 Oct 2012

Facio Flavia M, Sapp Julie C, Linn Amy, Biesecker Leslie G

Abstract excerpt

BACKGROUND: Massively-parallel sequencing (MPS) technologies create challenges for informed consent of research participants given the enormous scale of the data and the wide range of potential results. DISCUSSION: We propose that the consent process in these studies be based on whether they use MPS to test a hypothesis or to generate hypotheses. To demonstrate the differences in these approaches to informed...

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Identifiers

PMID: 23046515
DOI: 10.1186/1755-8794-5-45
PMCID: PMC3495642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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