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Article

The UCP1 -3826A/G polymorphism is associated with diabetic retinopathy and increased UCP1 and MnSOD2 gene expression in human retina.

Investigative ophthalmology & visual science - 1 Nov 2012

Brondani Letícia A, de Souza Bianca M, Duarte Guilherme C K, Kliemann Lúcia M, Esteves Jorge F, Marcon Alexandre S, Gross Jorge L, Canani Luís H, Crispim Daisy

Abstract excerpt

PURPOSE: Uncoupling protein 1 (UCP1) reduces mitochondrial production of reactive oxygen species (ROS). ROS overproduction is related to diabetic retinopathy (DR), a chronic complication of diabetes mellitus (DM). Therefore, deleterious polymorphisms in the UCP1 gene are candidate risk factors fo...

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Source

Identifiers

PMID: 23033381
DOI: 10.1167/iovs.12-10660

Genes

UCP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23033381-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The UCP1 -3826A/G polymorphism is associated with diabetic retinopathy and increased UCP1 and MnSOD2 gene expression in human retina.PMID 23033381Read ↗

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