Article
The ppm operon is essential for acylation and glycosylation of lipoproteins in Corynebacterium glutamicum.
PloS one - 1 Jan 2012
Mohiman Niloofar, Argentini Manuela, Batt Sarah M, Cornu David, Masi Muriel, Eggeling Lothar, Besra Gurdyal, Bayan Nicolas
Abstract excerpt
BACKGROUND: Due to their contribution to bacterial virulence, lipoproteins and members of the lipoprotein biogenesis pathway represent potent drug targets. Following translocation across the inner membrane, lipoprotein precursors are acylated by lipoprotein diacylglycerol transferase (Lgt), cleaved off their signal peptides by lipoprotein signal peptidase (Lsp) and, in Gram-negative bacteria, further triacylated...
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