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Secreted Vago restricts West Nile virus infection in <i>Culex</i> mosquito cells by activating the Jak-STAT pathway

1 Oct 2012

Abstract excerpt

Although West Nile virus (WNV) and other arthropod-borne viruses are a major public health problem, the mechanisms of antiviral immunity in mosquitoes are poorly understood. Dicer-2, responsible for the RNAi-mediated response through the C-terminal RNase-III domain, also contains an N-terminal DExD/H-box helicase domain similar to mammalian RIG-I/MDA5 which, in Drosophila, was found to be required for activation...

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PMID: 23027947
DOI: 10.1073/pnas.1205231109

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