Article
Lipid oxidation in carriers of lecithin:cholesterol acyltransferase gene mutations.
Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2012
Holleboom Adriaan G, Daniil Georgios, Fu Xiaoming, Zhang Renliang, Hovingh G Kees, Schimmel Alinda W, Kastelein John J P, Stroes Erik S G, Witztum Joseph L, Hutten Barbara A, Tsimikas Sotirios, Hazen Stanley L, Chroni Angeliki, Kuivenhoven Jan Albert
Abstract excerpt
OBJECTIVE: Lecithin:cholesterol acyltransferase (LCAT) has been shown to play a role in the depletion of lipid oxidation products, but this has so far not been studied in humans. In this study, we investigated processes and parameters relevant to lipid oxidation in carriers of functional LCAT mutations. METHODS AND RESULTS: In 4 carriers of 2 mutant LCAT alleles, 63 heterozygotes, and 63 family controls, we...
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