Human papillomavirus genotyping, human papillomavirus mRNA expression, and p16/Ki-67 cytology to detect anal cancer precursors in HIV-infected MSM.

doi:10.1097/QAD.0b013e328359f255

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Article

Human papillomavirus genotyping, human papillomavirus mRNA expression, and p16/Ki-67 cytology to detect anal cancer precursors in HIV-infected MSM.

AIDS (London, England) - 13 Nov 2012

Wentzensen Nicolas, Follansbee Stephen, Borgonovo Sylvia, Tokugawa Diane, Schwartz Lauren, Lorey Thomas S, Sahasrabuddhe Vikrant V, Lamere Brandon, Gage Julia C, Fetterman Barbara, Darragh Teresa M, Castle Philip E

Abstract excerpt

OBJECTIVE: Anal cancer incidence is high in HIV-infected MSM. Screening for anal intraepithelial lesions and cancers is performed at specialized clinics and relies on high-resolution anoscopy (HRA) and anal cytology. Both approaches have limited reproducibility and sensitivity for detecting anal cancer precursors. We evaluated biomarkers for human papillomavirus (HPV)-related disease in a population of...

Topics

Adult
Aged
Anal Canal
Anus Neoplasms
Biomarkers
California
Cross-Sectional Studies
Cyclin-Dependent Kinase Inhibitor p16
Follow-Up Studies
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homosexuality, Male

Human papillomavirus 16

Human papillomavirus 18

Humans

Ki-67 Antigen

Male

Middle Aged

Neoplasm Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23018436
DOI: 10.1097/QAD.0b013e328359f255
PMCID: PMC4144865

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23018436-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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