Article
Genetic polymorphisms in CYP1A1, GSTM1, GSTP1 and GSTT1 metabolic genes and risk of lung cancer in Asturias.
BMC cancer - 27 Sept 2012
López-Cima M Felicitas, Alvarez-Avellón Sara M, Pascual Teresa, Fernández-Somoano Ana, Tardón Adonina
Abstract excerpt
BACKGROUND: Metabolic genes have been associated with the function of metabolizing and detoxifying environmental carcinogens. Polymorphisms present in these genes could lead to changes in their metabolizing and detoxifying ability and thus may contribute to individual susceptibility to different types of cancer. We investigated if the individual and/or combined modifying effects of the CYP1A1 MspI T6235C, GSTM1...
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