Article
Molecular basis for the increased polymyxin susceptibility of Klebsiella pneumoniae strains with under-acylated lipid A.
Innate immunity - 1 Jun 2013
Velkov Tony, Soon Rachel L, Chong Pei L, Huang Johnny X, Cooper Matthew A, Azad Mohammad A K, Baker Mark A, Thompson Philip E, Roberts Kade, Nation Roger L, Clements Abigail, Strugnell Richard A, Li Jian
Abstract excerpt
The impact of under-acylation of lipid A on the interaction between Klebsiella pneumoniae LPS and polymyxins B and E was examined with fluorometric and calorimetric methods, and by (1)H NMR, using a paired wild type (WT) and the ΔlpxM mutant strains B5055 and B5055ΔlpxM, which predominantly express LPS with hexa- and penta-acylated lipid A structures respectively. LPS from B5055ΔlpxM displayed a fourfold...
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