Article
Neonatal protein kinase C zeta expression determines the neonatal T-Cell cytokine phenotype and predicts the development and severity of infant allergic disease.
Allergy - 1 Dec 2012
D'Vaz N, Ma Y, Dunstan J A, Lee-Pullen T F, Hii C, Meldrum S, Zhang G, Metcalfe J, Ferrante A, Prescott S L
Abstract excerpt
BACKGROUND: Previous studies have demonstrated that reduced T-cell protein kinase C zeta (PKCζ) expression is associated with allergy development in infants born to atopic mothers. This study examined whether this relationship extends to a general population and addressed the basis for the association. METHODS: A flow cytometry assay was developed for the measurement of T-cell PKCζ levels in PBMC, cord blood...
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