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Article

Chemotherapeutic sensitivity of testicular germ cell tumors under hypoxic conditions is negatively regulated by SENP1-controlled sumoylation of OCT4.

Cancer research - 1 Oct 2012

Wu Yu-Chih, Ling Thai-Yen, Lu Shing-Hwa, Kuo Hung-Chih, Ho Hong-Nerng, Yeh Shauh-Der, Shen Chia-Ning, Huang Yen-Hua

Abstract excerpt

Testicular germ cell tumors (TGCT) generally respond well to chemotherapy, but tumors that express low levels of the transcription factor OCT4 are associated with chemoresistance and poor prognosis. Hypoxia is known to induce drug resistance in TGCTs; however, the mechanistic basis for reduced expression of OCT4 and drug resistance is unclear. Here we show that hypoxia reduces OCT4 levels and increases the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23002208
DOI: 10.1158/0008-5472.CAN-12-0673

Genes

SENP1
SUMO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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