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Article

Enzyme redesign guided by cancer-derived IDH1 mutations.

Nature chemical biology - 1 Nov 2012

Reitman Zachary J, Choi Bryan D, Spasojevic Ivan, Bigner Darell D, Sampson John H, Yan Hai

Abstract excerpt

Mutations in an enzyme can result in a neomorphic catalytic activity in cancers. We applied cancer-associated mutations from isocitrate dehydrogenases to homologous residues in the active sites of homoisocitrate dehydrogenases to derive enzymes that catalyze the conversion of 2-oxoadipate to (R)-2-hydroxyadipate, a critical step for adipic acid production. Thus, we provide a prototypic example of how insights...

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Source

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Identifiers

PMID: 23001033
DOI: 10.1038/nchembio.1065
PMCID: PMC3487689

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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