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Article

A pentapeptide signature motif plays a pivotal role in Leishmania DNA topoisomerase IB activity and camptothecin sensitivity.

Biochimica et biophysica acta - 1 Dec 2012

Prada Christopher F, Alvarez-Velilla Raquel, Diaz-González Rosario, Prieto Carlos, Pérez-Pertejo Yolanda, Balaña-Fouce Rafael, Reguera Rosa M

Abstract excerpt

BACKGROUND: Leishmania donovani - the causative agent of visceral leishmaniasis - has several evolutionary characteristics that make the disease difficult to combat. Among these differences, a rare heterodimeric DNA topoisomerase IB has been reported thus opening a new promising field in the therapy of leishmaniasis. Several studies of the human enzyme have pointed to the importance of the linker domain in...

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Identifiers

PMID: 23000572
DOI: 10.1016/j.bbagen.2012.09.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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