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Article

N-terminal region of the large subunit of Leishmania donovani bisubunit topoisomerase I is involved in DNA relaxation and interaction with the smaller subunit.

The Journal of biological chemistry - 22 Apr 2005

Das Benu Brata, Sen Nilkantha, Dasgupta Somdeb Bose, Ganguly Agneyo, Majumder Hemanta K

Abstract excerpt

Leishmania donovani topoisomerase I is an unusual bisubunit enzyme. We have demonstrated earlier that the large and small subunit could be reconstituted in vitro to show topoisomerase I activity. We extend our biochemical study to evaluate the role of the large subunit in topoisomerase activity. The large subunit (LdTOP1L) shows a substantial degree of homology with the core DNA binding domain of the...

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Identifiers

PMID: 15711017
DOI: 10.1074/jbc.M412417200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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