Article
TYK2 rs34536443 polymorphism is associated with a decreased susceptibility to endometriosis-related infertility.
Human immunology - 1 Jan 2013
Peluso Carla, Christofolini Denise M, Goldman Cecília S, Mafra Fernanda A, Cavalcanti Viviane, Barbosa Caio P, Bianco Bianca
Abstract excerpt
INTRODUCTION: Tyrosine kinase 2 gene (TYK2) is part of the janus kinase (JAK) that binds to the type I interferon-α receptor (IFNAR) on the cell surface of IFN-producing cells, and have crucial importance in the etiology of autoimmune and inflammatory diseases. Many polymorphisms of the TYK2 gene have been identified, and recently, a number of case-control studies were conducted to investigate the association of...
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