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Article

Circulating trophoblastic cells provide genetic diagnosis in 63 fetuses at risk for cystic fibrosis or spinal muscular atrophy.

Reproductive biomedicine online - 1 Nov 2012

Mouawia Hussein, Saker Ali, Jais Jean-Philippe, Benachi Alexandra, Bussières Laurence, Lacour Bernard, Bonnefont Jean-Paul, Frydman René, Simpson Joe Leigh, Paterlini-Brechot Patrizia

Abstract excerpt

This study sought to determine whether a reliable non-invasive prenatal diagnosis (NI-PND) of cystic fibrosis (CF) or spinal muscular atrophy (SMA) can be achieved through analysis of circulating fetal trophoblastic cells (CFTC). The kinetics of CFTC circulation were also studied. CFTC were isolated by isolation by size of epithelial tumour/trophoblastic cells at 9-11 weeks of gestation, before chorionic villus...

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Source

Identifiers

PMID: 23000084
DOI: 10.1016/j.rbmo.2012.08.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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