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Article

Unusual optical resolution of all four tryptophan residues in MPT63 protein by phosphorescence spectroscopy: assignment and significance.

The journal of physical chemistry. B - 18 Oct 2012

Ghosh Ranendu, Mukherjee Manini, Chattopadhyay Krishnananda, Ghosh Sanjib

Abstract excerpt

MPT63, a secreted protein of unknown function that is specific to Mycobacterium tuberculosis and a potential drug target, contains four Tryptophan (Trp/W) residues located at positions 26, 48, 82, and 129 in the amino acid sequence. All of the four Trp residues have been optically resolved by simple inexpensive phosphorescence spectroscopy at 77 K. The protein architecture provides a delicate micro-environment...

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PMID: 22998652
DOI: 10.1021/jp307526f

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