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Article

Prevalence of amino acid mutations in hepatitis C virus core and NS5B regions among Venezuelan viral isolates and comparison with worldwide isolates.

Virology journal - 21 Sept 2012

Jaspe Rossana C, Sulbarán Yoneira F, Sulbarán Maria Z, Loureiro Carmen L, Rangel Hector R, Pujol Flor H

Abstract excerpt

BACKGROUND: Recent reports show that R70Q and L/C91M amino acid substitutions in the core from different hepatitis C virus (HCV) genotypes have been associated with variable responses to interferon (IFN) and ribavirin (RBV) therapy, as well to an increase of hepatocellular carcinoma (HCC) risk, liver steatosis and insulin resistance (IR). Mutations in NS5B have also been associated to IFN, RBV, nucleoside and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22995142
DOI: 10.1186/1743-422X-9-214
PMCID: PMC3511240

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Source receipt: pubmed, retrieved 7 Sept 2026.

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