Article
Molecular diagnostics and personalized medicine in oncology: challenges and opportunities.
Journal of cellular biochemistry - 1 Mar 2013
Normanno Nicola, Rachiglio Anna Maria, Roma Cristin, Fenizia Francesca, Esposito Claudia, Pasquale Raffaella, La Porta Maria Libera, Iannaccone Alessia, Micheli Filippo, Santangelo Michele, Bergantino Francesca, Costantini Susan, De Luca Antonella
Abstract excerpt
Increasing evidence demonstrates that target-based agents are active only in molecularly selected populations of patients. Therefore, the identification of predictive biomarkers has become mandatory to improve the clinical development of these novel drugs. Mutations of the epidermal growth factor receptor (EGFR) or rearrangements of the ALK gene in non-small-cell lung cancer, and BRAF mutations in melanoma are...
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