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Article

Do mesenchymal stem cells function across species barriers? Relevance for xenotransplantation

1 Sept 2012

Abstract excerpt

BACKGROUND: Allogeneic mesenchymal stem (stromal) cells (MSC) are a promising therapy for various pathological conditions. Genetically modified pig MSC have been demonstrated to downregulate the human T-cell response to pig antigens in vitro. Before genetically modified pig MSC can be used clinically, however, evidence needs to be provided to indicate whether they will survive in a human (xenogeneic) host....

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PMID: 22978461
DOI: 10.1111/xen.12000

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