Snap helix with knob and hole: essential repeats in S. pombe nuclear protein nuc2+.

doi:10.1016/0092-8674(90)90746-2

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Snap helix with knob and hole: essential repeats in S. pombe nuclear protein nuc2+.

Cell - 26 Jan 1990

Hirano T, Kinoshita N, Morikawa K, Yanagida M

Abstract excerpt

The S. pombe nuc2+ gene is required for mitotic chromosome disjunction. Its mutation arrests mitosis at the metaphase. The gene product is present in the nuclear scaffold-like fraction. The nuc2+ protein contains a domain, separated from ten 34 amino acid repeat segments, that is capable of binding AT-rich DNA in vitro. The ts mutation resides in one of the 34 amino acid repeats. Circular dichroism, limited...

Topics

Amino Acid Sequence
Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome
Chromatography, Affinity
Circular Dichroism
Computer Graphics
DNA-Binding Proteins
Fungal Proteins
Genes, Fungal
Kinetics
Mitosis
Models, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Structural

Molecular Sequence Data

Mutation

Nuclear Proteins

Plasmids

Protein Conformation

Repetitive Sequences, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 2297790
DOI: 10.1016/0092-8674(90)90746-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2297790-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Snap helix with knob and hole: essential repeats in S. pombe nuclear protein nuc2+.PMID 2297790Read ↗

Inner nuclear membrane protein Lem2 augments heterochromatin formation in response to nutritional conditions.Semantic proximity Read ↗

A remarkable case of conserved domain swapping in the COMMD family of proteinsSemantic proximity Read ↗

Involvement of SRD2-mediated activation of snRNA transcription in the control of cell proliferation competence in Arabidopsis.Semantic proximity Read ↗

A screen for genes involved in the anaphase proteolytic pathway identifies tsm1(+), a novel Schizosaccharomyces pombe gene important for microtubule integrity.Semantic proximity Read ↗

The chromatin-associated protein H-NS.Semantic proximity Read ↗

Characterization of the NSE6 subunit of the <i>Physcomitrium patens</i> PpSMC5/6 complexSemantic proximity Read ↗

Fission yeast TPR-family protein nuc2 is required for G1-arrest upon nitrogen starvation and is an inhibitor of septum formation.Semantic proximity Read ↗

Identification of a human homologue of yeast nuc2 which interacts with the retinoblastoma protein in a specific manner.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.