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Article

Snap helix with knob and hole: essential repeats in S. pombe nuclear protein nuc2+.

Cell - 26 Jan 1990

Hirano T, Kinoshita N, Morikawa K, Yanagida M

Abstract excerpt

The S. pombe nuc2+ gene is required for mitotic chromosome disjunction. Its mutation arrests mitosis at the metaphase. The gene product is present in the nuclear scaffold-like fraction. The nuc2+ protein contains a domain, separated from ten 34 amino acid repeat segments, that is capable of binding AT-rich DNA in vitro. The ts mutation resides in one of the 34 amino acid repeats. Circular dichroism, limited...

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Identifiers

PMID: 2297790
DOI: 10.1016/0092-8674(90)90746-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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