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FoxM1 Inhibition Sensitizes Resistant Glioblastoma Cells to Temozolomide by Downregulating the Expression of DNA-Repair Gene <i>Rad51</i>

12 Sept 2012

Abstract excerpt

PURPOSE: Recurrent glioblastoma multiforme (GBM) is characterized by resistance to radiotherapy and chemotherapy and a poor clinical prognosis. In this study, we investigated the role of the oncogenic transcription factor FoxM1 in GBM cells' resistance to alkylator temozolomide (TMZ) and its potential molecular mechanism. EXPERIMENTAL DESIGN: FoxM1 expression levels were measured by immunohistochemical analysis...

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PMID: 22977194
DOI: 10.1158/1078-0432.ccr-12-0039

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