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Article

Extra-binomial variation approach for analysis of pooled DNA sequencing data.

Bioinformatics (Oxford, England) - 15 Nov 2012

Yang Xin, Todd John A, Clayton David, Wallace Chris

Abstract excerpt

MOTIVATION: The invention of next-generation sequencing technology has made it possible to study the rare variants that are more likely to pinpoint causal disease genes. To make such experiments financially viable, DNA samples from several subjects are often pooled before sequencing. This induces...

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Identifiers

PMID: 22976083
DOI: 10.1093/bioinformatics/bts553
PMCID: PMC3496343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22976083-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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