Article
Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects.
Journal of medical genetics - 1 Sept 2012
Lill Christina M, Liu Tian, Schjeide Brit-Maren M, Roehr Johannes T, Akkad Denis A, Damotte Vincent, Alcina Antonio, Ortiz Miguel A, Arroyo Rafa, Lopez de Lapuente Aitzkoa, Blaschke Paul, Winkelmann Alexander, Gerdes Lisa-Ann, Luessi Felix, Fernadez Oscar, Izquierdo Guillermo, Antigüedad Alfredo, Hoffjan Sabine, Cournu-Rebeix Isabelle, Gromöller Silvana, Faber Hans, Liebsch Maria, Meissner Esther, Chanvillard Coralie, Touze Emmanuel, Pico Fernando, Corcia Philippe, Dörner Thomas, Steinhagen-Thiessen Elisabeth, Baeckman Lars, Heekeren Hauke R, Li Shu-Chen, Lindenberger Ulman, Chan Andrew, Hartung Hans-Peter, Aktas Orhan, Lohse Peter, Kümpfel Tania, Kubisch Christian, Epplen Joerg T, Zettl Uwe K, Fontaine Bertrand, Vandenbroeck Koen, Matesanz Fuencisla, Urcelay Elena, Bertram Lars, Zipp Frauke
Abstract excerpt
BACKGROUND: Single nucleotide polymorphisms (SNPs) rs429358 (ε4) and rs7412 (ε2), both invoking changes in the amino-acid sequence of the apolipoprotein E (APOE) gene, have previously been tested for association with multiple sclerosis (MS) risk. However, none of these studies was sufficiently po...
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