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Article

Influence of peptide dipoles and hydrogen bonds on reactive cysteine pKa values in fission yeast DJ-1.

The FEBS journal - 1 Nov 2012

Madzelan Peter, Labunska Tetyana, Wilson Mark A

Abstract excerpt

Cysteine residues with depressed pK(a) values are critical for the functions of many proteins. Several types of interactions can stabilize cysteine thiolate anions, including hydrogen bonds between thiol(ate)s and nearby residues as well as electrostatic interactions involving charged residues or...

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Identifiers

PMID: 22971103
DOI: 10.1111/febs.12004
PMCID: PMC3484204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22971103-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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