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Article

Influence of peptide dipoles and hydrogen bonds on reactive cysteine pKa values in fission yeast DJ-1.

The FEBS journal - 1 Nov 2012

Madzelan Peter, Labunska Tetyana, Wilson Mark A

Abstract excerpt

Cysteine residues with depressed pK(a) values are critical for the functions of many proteins. Several types of interactions can stabilize cysteine thiolate anions, including hydrogen bonds between thiol(ate)s and nearby residues as well as electrostatic interactions involving charged residues or dipoles. Dipolar stabilization of thiolates by peptide groups has been suggested to play a particularly important role...

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Identifiers

PMID: 22971103
DOI: 10.1111/febs.12004
PMCID: PMC3484204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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