Article
A conserved arginine plays a role in the catalytic cycle of the protein disulphide isomerases.
Journal of molecular biology - 2 Jan 2004
Lappi A K, Lensink M F, Alanen H I, Salo K E H, Lobell M, Juffer A H, Ruddock L W
Abstract excerpt
The pK(a) values of the CXXC active-site cysteine residues play a critical role in determining the physiological function of the thioredoxin superfamily. To act as an efficient thiol-disulphide oxidant the thiolate state of the N-terminal cysteine must be stabilised and the thiolate state of the C-terminal cysteine residue destabilised. While increasing the pK(a) value of the C-terminal cysteine residue promotes...
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