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Limitations of encapsidation of recombinant self-complementary adeno-associated viral genomes in different serotype capsids and their quantitation.

Human gene therapy methods - 1 Aug 2012

Wang Yuan, Ling Chen, Song Liujiang, Wang Lina, Aslanidi George V, Tan Mengqun, Ling Changquan, Srivastava Arun

Abstract excerpt

We previously reported that self-complementary adeno-associated virus (scAAV) type 2 genomes of up to 3.3 kb can be successfully encapsidated into AAV2 serotype capsids. Here we report that such oversized AAV2 genomes fail to undergo packaging in other AAV serotype capsids, such as AAV1, AAV3, AAV6, and AAV8, as determined by Southern blot analyses of the vector genomes, although hybridization signals on...

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Identifiers

PMID: 22966785
DOI: 10.1089/hgtb.2012.090
PMCID: PMC4015078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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