The Cancer Preventive Flavonoid Silibinin Causes Hypophosphorylation of Rb/p107 and Rb2/p130 Via Modulation of Cell Cycle Regulators in Human Prostate Carcinoma DU145 Cells

Abstract excerpt

Phosphorylation status of retinoblastoma (Rb) and related proteins is important to drive cell cycle progression. In hyperphosphorylated state, they are growth stimulatory, but their hypophosphorylation is growth inhibitory. Here we assessed whether silibinin causes hypophosphorylation of Rb-related proteins as its growth inhibitory response in human prostate cancer (PCA) DU145 cells. Silibinin treatment of cells...

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