Article
Intestinal tissues induce an SNP mutation in Pseudomonas aeruginosa that enhances its virulence: possible role in anastomotic leak.
PloS one - 1 Jan 2012
Olivas Andrea D, Shogan Benjamin D, Valuckaite Vesta, Zaborin Alexander, Belogortseva Natalya, Musch Mark, Meyer Folker, Trimble William L, An Gary, Gilbert Jack, Zaborina Olga, Alverdy John C
Abstract excerpt
The most feared complication following intestinal resection is anastomotic leakage. In high risk areas (esophagus/rectum) where neoadjuvant chemoradiation is used, the incidence of anastomotic leaks remains unacceptably high (≈ 10%) even when performed by specialist surgeons in high volume centers. The aims of this study were to test the hypothesis that anastomotic leakage develops when pathogens colonizing...
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