Article
Human monoclonal antibody MBL-HCV1 delays HCV viral rebound following liver transplantation: a randomized controlled study.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Apr 2013
Chung R T, Gordon F D, Curry M P, Schiano T D, Emre S, Corey K, Markmann J F, Hertl M, Pomposelli J J, Pomfret E A, Florman S, Schilsky M, Broering T J, Finberg R W, Szabo G, Zamore P D, Khettry U, Babcock G J, Ambrosino D M, Leav B, Leney M, Smith H L, Molrine D C
Abstract excerpt
Rapid allograft infection complicates liver transplantation (LT) in patients with hepatitis C virus (HCV). Pegylated interferon-α and ribavirin therapy after LT has significant toxicity and limited efficacy. The effect of a human monoclonal antibody targeting the HCV E2 glycoprotein (MBL-HCV1) on viral clearance was examined in a randomized, double-blind, placebo-controlled pilot study in patients infected with...
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