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Article

Changing the start codon context of the 30K gene of tobacco mosaic virus from "weak" to "strong" does not increase expression.

Virology - 1 Jan 1990

Lehto K, Dawson W O

Abstract excerpt

The translation initiation region of the 30K gene of tobacco mosaic virus (TMV) was modified by in vitro mutagenesis to create more optimal start codon contexts. A complicating factor was that modifications in this region also altered the 3' terminus of the 183K ORF that overlaps the 30K ORF. An insertion of GACUCGA between nucleotides 4901 and 4902 resulted in a purine (G) in position -3 relative to the AUG...

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PMID: 2294639
DOI: 10.1016/0042-6822(90)90065-y

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