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Article

Complex regulation of voltage-dependent activation and inactivation properties of retinal voltage-gated Cav1.4 L-type Ca2+ channels by Ca2+-binding protein 4 (CaBP4).

The Journal of biological chemistry - 19 Oct 2012

Shaltiel Lior, Paparizos Christos, Fenske Stefanie, Hassan Sami, Gruner Christian, Rötzer Katrin, Biel Martin, Wahl-Schott Christian A

Abstract excerpt

Cav1.4 L-type Ca(2+) channels are crucial for synaptic transmission in retinal photoreceptors and bipolar neurons. Recent studies suggest that the activity of this channel is regulated by the Ca(2+)-binding protein 4 (CaBP4). In the present study, we explored this issue by examining functional effects of CaBP4 on heterologously expressed Cav1.4. We show that CaBP4 dramatically increases Cav1.4 channel...

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Identifiers

PMID: 22936811
DOI: 10.1074/jbc.M112.392811
PMCID: PMC3476298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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