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Article

Cav1.4 dysfunction and congenital stationary night blindness type 2.

Pflugers Archiv : European journal of physiology - 1 Sept 2021

Koschak Alexandra, Fernandez-Quintero Monica L, Heigl Thomas, Ruzza Marco, Seitter Hartwig, Zanetti Lucia

Abstract excerpt

Cav1.4 L-type Ca2+ channels are predominantly expressed in retinal neurons, particularly at the photoreceptor terminals where they mediate sustained Ca2+ entry needed for continuous neurotransmitter release at their ribbon synapses. Cav1.4 channel gating properties are controlled by accessory subunits, associated regulatory proteins, and also alternative splicing. In humans, mutations in the CACNA1F gene encoding...

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Identifiers

PMID: 34212239
DOI: 10.1007/s00424-021-02570-x
PMCID: PMC8370969

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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