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Article

[Effect of genetic polymorphism of TPMT and NUDT15 on the tolerance of 6-mercaptopurine therapy in adult acute lymphoblastic leukemia].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 14 Nov 2021

Hao Q S, Wang Z, Fang Q Y, Gong X Y, Liu K Q, Li Y, Wei H, Wang Y, Li Q H, Wang M, Tian Z, Wang J X, Mi Y C

Abstract excerpt

Objective: To investigate the effect of genetic polymorphisms of TPMT*2 rs1800462, TPMT*3B rs1800460, TPMT*3C rs1142345, and NUDT15 rs116855232 on the tolerance of 6-mercaptopurine (6-MP) therapy in adult acute lymphoblastic leukemia (ALL) . Methods: A total of 216 adult patients who were diagnosed with ALL and treated with cyclophosphamide, cytarabine, and 6-MP [complementary and alternative medicine (CAM)...

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Share to Antimetabolites, Antineoplastic
Share to Genotype
Share to Mercaptopurine
Share to Methyltransferases
Share to Polymorphism, Genetic
Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma
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Source

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Identifiers

PMID: 35045652
DOI: 10.3760/cma.j.issn.0253-2727.2021.11.005
PMCID: PMC8763585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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