Changes in the Distribution of Mouse Oocyte Cortical Granules and Ability to Undergo the Cortical Reaction during Gonadotropin-stimulated Meiotic Maturation and Aging in Vivo1

Abstract excerpt

Mouse oocyte cortical granule (CG) activation and distribution were investigated during in vivo meiotic maturation to determine the onset of competence to undergo the cortical reaction, which is considered responsible for the block to polyspermy. In the present study, the resumption of oocyte maturation was stimulated by hCG administration. Competence to undergo the cortical reaction (assessed with calcium...

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