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Article

Secondary mutation in a coding mononucleotide tract in MSH6 causes loss of immunoexpression of MSH6 in colorectal carcinomas with MLH1/PMS2 deficiency

24 Aug 2012

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 22918162
DOI: 10.1038/modpathol.2012.138

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Related research

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Secondary mutation in a coding mononucleotide tract in MSH6 causes loss of immunoexpression of MSH6 in colorectal carcinomas with MLH1/PMS2 deficiencyPMID 22918162Read ↗

Identification of new genetic alterations in MLH1, MSH2 and MSH6 using IHC and HRM analysis in Lynch syndrome-suspected patientsSemantic proximity Read ↗

An unusual tumor spectrum in Lynch syndrome caused by MSH6 mutationSemantic proximity Read ↗

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Cancer Risks Associated With Germline Mutations in MLH1, MSH2, and MSH6 Genes in Lynch SyndromeSemantic proximity Read ↗

Somatic Mutations in MLH1 and MSH2 Are a Frequent Cause of Mismatch-Repair Deficiency in Lynch Syndrome-Like TumorsSemantic proximity Read ↗

Next generation sequencing to decipher concurrent loss of PMS2 and MSH6 in colorectal cancer.Semantic proximity Read ↗

Early age of onset and broad cancer spectrum persist in MSH6- and PMS2-associated Lynch syndromeSemantic proximity Read ↗

MSH6-proficient crypt foci in MSH6 constitutional mismatch repair deficiency: reversion of a frameshifted coding microsatellite to its wild-type sequenceSemantic proximity Read ↗

An Ashkenazi founder mutation in the MSH6 gene leading to HNPCC.Semantic proximity Read ↗

Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancerSemantic proximity Read ↗

Concurrent loss of MLH1, PMS2 and MSH6 immunoexpression in digestive system cancers indicating a widespread dysregulation in DNA repair processesSemantic proximity Read ↗

Acquired somatic MMR deficiency is a major cause of MSI tumor in patients suspected for “Lynch-like syndrome” including young patientsSemantic proximity Read ↗

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