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Article

Do MSH6 mutations contribute to double primary cancers of the colorectum and endometrium?

Human genetics - 1 Dec 2000

Charames G S, Millar A L, Pal T, Narod S, Bapat B

Abstract excerpt

Mismatch repair (MMR) gene mutations cause hereditary nonpolyposis colorectal cancer (HNPCC), a common form of familial colorectal cancer. Among MMR genes, germline MSH6 mutations are often observed in HNPCC-like families with an increased frequency of endometrial cancer. We have previously shown that a proportion of women affected with double primary cancers of the colorectum and endometrium carry germline MSH2...

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11153917
DOI: 10.1007/s004390000417

Genes

MSH6
MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Do MSH6 mutations contribute to double primary cancers of the colorectum and endometrium?PMID 11153917Read ↗

Mutation analysis of the MLH1, MSH2 and MSH6 genes in patients with double primary cancers of the colorectum and the endometrium: a population-based study in northern Sweden.Semantic proximity Read ↗

A mosaic pathogenic variant in MSH6 causes MSH6-deficient colorectal and endometrial cancer in a patient classified as suspected Lynch syndrome: a case reportSemantic proximity Read ↗

Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancerSemantic proximity Read ↗

Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillanceSemantic proximity Read ↗

Identification of a novel MSH6 germline variant in a family with multiple gastro-intestinal malignancies by next generation sequencing.Semantic proximity Read ↗

Mismatch repair gene defects contribute to the genetic basis of double primary cancers of the colorectum and endometrium.Semantic proximity Read ↗

MSH6 missense mutations are often associated with no or low cancer susceptibility.Semantic proximity Read ↗

Lower incidence of colorectal cancer and later age of disease onset in 27 families with pathogenic MSH6 germline mutations compared with families with MLH1 or MSH2 mutations: the German Hereditary Nonpolyposis Colorectal Cancer Consortium.Semantic proximity Read ↗

Atypical HNPCC owing to MSH6 germline mutations: analysis of a large Dutch pedigree.Semantic proximity Read ↗

Secondary mutation in a coding mononucleotide tract in MSH6 causes loss of immunoexpression of MSH6 in colorectal carcinomas with MLH1/PMS2 deficiencySemantic proximity Read ↗

Two Swedish founder MSH6 mutations, one nonsense and one missense, conferring high cumulative risk of Lynch syndrome.Semantic proximity Read ↗

Ovarian cancer of endometrioid type as part of the MSH6gene mutation phenotype.Semantic proximity Read ↗

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