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Article

Organotypic coculture preparation for the study of developmental synapse elimination in mammalian brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 Aug 2012

Uesaka Naofumi, Mikuni Takayasu, Hashimoto Kouichi, Hirai Hirokazu, Sakimura Kenji, Kano Masanobu

Abstract excerpt

We developed an organotypic coculture preparation allowing fast and efficient identification of molecules that regulate developmental synapse elimination in the mammalian brain. This coculture consists of a cerebellar slice obtained from rat or mouse at postnatal day 9 (P9) or P10 and a medullary explant containing the inferior olive dissected from rat at embryonic day 15. We verified that climbing fibers (CFs),...

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Identifiers

PMID: 22915109
DOI: 10.1523/JNEUROSCI.1097-12.2012
PMCID: PMC6703771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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