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Article

HLA-A*0206 with TLR3 polymorphisms exerts more than additive effects in Stevens-Johnson syndrome with severe ocular surface complications.

PloS one - 1 Jan 2012

Ueta Mayumi, Tokunaga Katsushi, Sotozono Chie, Sawai Hiromi, Tamiya Gen, Inatomi Tsutomu, Kinoshita Shigeru

Abstract excerpt

BACKGROUND: Stevens-Johnson syndrome (SJS) is an acute inflammatory vesiculobullous reaction of the skin and mucosa, often including the ocular surface, and toxic epidermal necrolysis (TEN) occurs with its progression. Although SJS/TEN is thought to be initiated by certain types of medication coupled with possible infection. In the present study we examined the multiplicative interaction(s) between HLA-A*0206 and...

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Identifiers

PMID: 22912896
DOI: 10.1371/journal.pone.0043650
PMCID: PMC3422242

Genes

TLR3

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