Article
High expression of nuclear factor 90 (NF90) leads to mitochondrial degradation in skeletal and cardiac muscles.
PloS one - 1 Jan 2012
Higuchi Takuma, Sakamoto Shuji, Kakinuma Yoshihiko, Kai Shoko, Yagyu Ken-Ichi, Todaka Hiroshi, Chi Eunsup, Okada Shoshiro, Ujihara Takako, Morisawa Keiko, Ono Masafumi, Sugiyama Yasunori, Ishida Waka, Fukushima Atsuki, Tsuda Masayuki, Agata Yasutoshi, Taniguchi Taketoshi
Abstract excerpt
While NF90 has been known to participate in transcription, translation and microRNA biogenesis, physiological functions of this protein still remain unclear. To uncover this, we generated transgenic (Tg) mice using NF90 cDNA under the control of β-actin promoter. The NF90 Tg mice exhibited a reduction in body weight compared with wild-type mice, and a robust expression of NF90 was detected in skeletal muscle,...
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