Article
Early sorafenib-induced toxicity is associated with drug exposure and UGTIA9 genetic polymorphism in patients with solid tumors: a preliminary study.
PloS one - 1 Jan 2012
Boudou-Rouquette Pascaline, Narjoz Céline, Golmard Jean Louis, Thomas-Schoemann Audrey, Mir Olivier, Taieb Fabrice, Durand Jean-Philippe, Coriat Romain, Dauphin Alain, Vidal Michel, Tod Michel, Loriot Marie-Anne, Goldwasser François, Blanchet Benoit
Abstract excerpt
BACKGROUND: Identifying predictive biomarkers of drug response is of key importance to improve therapy management and drug selection in cancer therapy. To date, the influence of drug exposure and pharmacogenetic variants on sorafenib-induced toxicity remains poorly documented. The aim of this pharmacokinetic/pharmacodynamic (PK/PD) study was to investigate the relationship between early toxicity and drug exposure...
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