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Article

Shedding of TRAP by a rhomboid protease from the malaria sporozoite surface is essential for gliding motility and sporozoite infectivity.

PLoS pathogens - 1 Jan 2012

Ejigiri Ijeoma, Ragheb Daniel R T, Pino Paco, Coppi Alida, Bennett Brandy Lee, Soldati-Favre Dominique, Sinnis Photini

Abstract excerpt

Plasmodium sporozoites, the infective stage of the malaria parasite, move by gliding motility, a unique form of locomotion required for tissue migration and host cell invasion. TRAP, a transmembrane protein with extracellular adhesive domains and a cytoplasmic tail linked to the actomyosin motor, is central to this process. Forward movement is achieved when TRAP, bound to matrix or host cell receptors, is...

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Identifiers

PMID: 22911675
DOI: 10.1371/journal.ppat.1002725
PMCID: PMC3406075

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Source receipt: pubmed, retrieved 7 Sept 2026.

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