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Article

Functional characterization of the iron-regulatory transcription factor Fep1 from Schizosaccharomyces pombe.

The Journal of biological chemistry - 1 Jul 2005

Pelletier Benoit, Trott Amy, Morano Kevin A, Labbé Simon

Abstract excerpt

In response to excess iron, Schizosaccharomyces pombe cells repress transcription of genes encoding components involved in iron uptake through the Fep1 transcription factor. Fep1 mediates this control by interacting with the consensus sequence 5'-(A/T)GATAA-3', found in iron-dependent promoters. In this report, we show that Fep1 localizes to the nucleus under both iron-replete and iron-starved conditions. The...

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PMID: 15866870
DOI: 10.1074/jbc.M502947200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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